More proof the mRNAs rewire the immune system with unknown long-term effects

 

Many people who receive mRNA Covid jabs wind up with profound changes in their immune systems that usually arise only after prolonged exposure to allergens like bee venom, a new study confirms.

The changes seem to reduce the immune response to Covid as the body adjusts to the unnaturally high antibody levels mRNA jabs initially produce.

They may account for the paradoxical fact that despite Omicron’s mildness, jab fanatics like Stephen Colbert recently have reported failing to clear Covid infections quickly. The immune system changes are unique to mRNA and not seen in people who get other kinds of Covid vaccines, the study found. 

Scientists in the Netherlands carried out the study, which included 604 patients and was funded by the Dutch government.

In each paper, scientists reported people who had received at least three mRNA shots showed a sharp increase in a type of antibodies called IgG4.

IgG antibodies persist for months in the blood after someone is infected with an “antigen” - a foreign invader like the coronavirus. They are the most common antibodies the immune system produces. 

In the case of the coronavirus, IgG antibodies attach to the spike protein that juts out from the surface of the virus. They then either prevent the virus from locking on the body’s cells and reproducing, or recruit other parts of the immune system to attack the virus. 

But IgG antibodies come in different subclasses. 

IgG4 is generally the rarest, and the last the body makes. The IgG4 subtype does not recruit other parts of the immune system to attack the virus, though can still “neutralize” the virus by keeping the virus from attaching to cells. Usually, the IgG4 class make up less than 5 percent of all IgG antibodies, and often less than 1 percent. 

But the scientists found that after a third shot, IgG4 made up about 21 percent of all the IgG antibodies they found in the average healthy adult. The levels varied very widely, though, and in 1 in 4 adults IgG4 was nearly 50 percent of all IgG antibodies. 

Because IgG4 is so uncommon when the immune system is working normally, no one really knows what the impact of much-higher-than-normal IgG4 levels may be. “Accurately deciphering the negative consequences, if any, of increased IgG4 levels will be difficult,” one expert wrote in January, after the first IgG4 papers appeared. 

But the uncertainties don’t end there. 

No one knows whether IgG4 levels will keep rising with further boosters or repeated Covid infections. No one knows whether Omicron’s spike will keep mutating away from the antibodies that people who receive the initial vaccines made.

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