4 June 1942: Midway
At Midway the US Navy lost the carrier Yorktown. The other two American carriers Enterprise and Hornet were not even scratched. The Hornet was sunk during the Guadalcanal campaign at the Battle of the Santa Cruz Islands on October, 26 1942. The Enterprise, which didn't seem to miss any battle in the Pacific, survived the war.
Sadly, The Big E did not survive the Truman and Eisenhower administrations. If you can believe it, she was scrapped in July 1958.
Crossposted at The Dougout