Paxlovid can cause serious health problems when coupled with common heart disease medication such as statins and blood thinners.
Researchers from Lahey Hospital and Medical Center, Harvard Medical School and other US institutions found the Covid drug can increase the risk of developing blood clots when taken with blood thinners.
It can also cause an irregular heartbeat when combined with drugs for heart pain and when taken alongside statins it can be toxic to the liver.
Dozens of medications such as aspirin are safe to take with Paxlovid, the researchers stress. But doctors need to be aware that other drugs can be dangerous and should be discontinued or adjusted while a patient is being treated for Covid.
Dr. Sarju Ganatra, director of the cardio-oncology program at Lahey Hospital and Medical Center in Massachusetts, said: 'Awareness of the presence of drug-drug interactions of Paxlovid with common cardiovascular drugs is key.
'System-level interventions by integrating drug-drug interactions into electronic medical records could help avoid related adverse events.
'The prescription of Paxlovid could be incorporated into an order set, which allows physicians, whether it be primary care physicians or cardiology providers, to consciously rule out any contraindications to the co-administration of Paxlovid.
'Consultation with other members of the health care team, particularly pharmacists, can prove to be extremely valuable.
'However, a health care provider’s fundamental understanding of the drug-drug interactions with cardiovascular medications is key.'
Paxlovid is made of two antivirals, nirmatrelvir and ritonavir.
Dr Dan Barouch, director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center in Boston, who was not involved in the new paper, told CNN: 'The second drug, ritonavir, is a nonspecific drug that inhibits metabolism and increases the dose of the other drug.
Dr. Jennifer Brown commentary:
Plaxovid has a moderate to dangerous drug to drug interaction with MORE PRESCRIPTION MEDICATIONS than any other drug on the market. And remember, the FDA gave PHARMACISTS the authorization to dispense the med WITHOUT A PRESCRIPTION!!!!! Even though it is not an over the counter med and requires a prescription to get it filled. I know of one provider who wrote a prescription for himself, with zero knowledge that it would interfere with hypertension and statin drugs. That they take. How can we expect every patient to go to their usual pharmacy where their current drug profile is on record to verify no interactions? This has the potential to kill someone.
This should have never been approved for public use. It is a very dangerous drug.
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