Don’t take it from me, I don’t even get to tweet anymore.
Take it from a little place I call the British government. Which admitted today, in its newest vaccine surveillance report, that:
“N antibody levels appear to be lower in people who acquire infection following two doses of vaccination.” (Page 23)
[…]
Small increases in Roche N seropositivity have recently been observed across all age groups (Table 6) compared to the previous 12-week period. Increases in the overall COVID-19 case rates in England have been observed across all age groups and regions in week 40 (Weekly national Influenza and COVID-19 surveillance report week 41). Roche S seropositivity in blood donors has plateaued and is now over 96% across all age groups. Seropositivity estimates for S antibody in blood donors are likely to be higher than would be expected in the general population and this probably reflects the fact that donors are more likely to be vaccinated. Seropositivity estimates for N antibody will underestimate the proportion of the population previously infected due to (i) blood donors are potentially less likely to be exposed to natural infection than age matched individuals in the general population (ii) waning of the N antibody response over time and (iii) recent observations from UK Health Security Agency (UKHSA) surveillance data that N antibody levels appear to be lower in individuals who acquire infection following 2 doses of vaccination. Vaccination has made an important contribution to the overall Roche S increases observed since the roll out of the vaccination programme, initially amongst individuals aged 50 years and above who were prioritised for vaccination as part of the phase 1 programme and more recently in younger adults as part of phase 2 of the vaccination programme.
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